تحضير وتشخيص ودراسة الالتحام الجزيئي لمركبات 1،3 ثيازينان -4-اون المحضرة عن طريق تفاعل حامض 3-مركبتوبروبانويك مع قواعد شف

المؤلفون

  • عمر جمال مهدي جامعة الأنبار / كلية التربية للعلوم الصرفة/ قسم الكيمياء جامعة الأنبار image/svg+xml

DOI:

https://doi.org/10.31185/bsj.Vol21.Iss38.1516

الكلمات المفتاحية:

1,3-ثيازينان -4-ون، إيمين، قواعد شيف، حامض 3-مركابتوبروبانويك، الالتحام الجزيئي.

الملخص

     في هذا العمل، تمّ تحضير أربع مركبات ذات حلقات سداسية غير متجانسة (K1-K4) باستخدام قواعد شف والكواشف المناسبة. ولتحضير قواعد شيف، تمّ تكثيف 4-كلوروأنيلين مع ألدهيدات عطرية مختلفة في الإيثانول المطلق مع بضع قطرات من حمض الخليك الثلجي كعامل مساعد. تم الحصول على مشتق 1،3-ثيازينان-4-ون المعوض من مفاعلة قواعد شف المحضرة مع حامض 3-مركابتوبروبانويك في البنزين اللامائي بالتصعيد الارتجاجي. عُزلت المنتجات ونُقيت ووُصفت باستخدام مطيافية الأشعة تحت الحمراء بتحويل فورييه ، ومطيافية الرنين النووي المغناطيسي للبروتون ومطيافية الكتلة، والتحليل الدقيق للعناصر ، استُخدمت تقنية الالتحام الجزيئي لدراسة التأثيرات المثبطة للمركبات المُنتجة (K1-K4) على نشاط أستيل كولين إستراز (AChE). أظهرت جميع مشتقات 1،3-ثيازينان-4-ون نشاطًا مثبطًا للإنزيم. وكشف المشتق K1، بدرجة إرساء -9.3 كيلو كالوري/مول، عن تأثيرات مثبطة جيدة على تثبيط AChE مقارنةً بالجالانثامين، الذي استُخدم كدواء مرجعي.

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التنزيلات

منشور

2026-03-01

إصدار

القسم

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