تأثير المعادن الثقيلة على مضادات الأكسدة و وظائف الكبد في المنطقة الصناعية لمدينة الموصل
DOI:
https://doi.org/10.31185/bsj.Vol22.Iss40.1599الكلمات المفتاحية:
المنطقة الصناعية ,الرصاص ,الكروم ,مالونديالدهيد ,الكلوتاثايون,انزيمات الكبدالملخص
يُمثل تلوث المعادن الثقيلة تحديًا بيئيًا وصحيًا عامًا متزايدًا، لا سيما في المجتمعات القريبة من المناطق الصناعية. يُعدّ الرصاص والكروم الثلاثي من أكثر المعادن الثقيلة إثارة للقلق نظرًا لتأثيراتهما السمية المُوثّقة جيدًا على العديد من أجهزة الجسم. يمكن أن يدخل كلا المعدنين جسم الإنسان عن طريق استنشاق الهواء الملوث، أو تناول الطعام أو الماء الملوث، أو ملامسة الجلد للغبار الصناعي. يرتبط التعرض المزمن لهذه الملوثات بزيادة الإجهاد التأكسدي، واختلال آليات الدفاع الخلوية المضادة للأكسدة، وإصابة الخلايا الكبدية. يمكن أن يحدث الإجهاد التأكسدي عندما يتجاوز إنتاج أنواع الأكسجين التفاعلية ومنتجات بيروكسيد الدهون، مثل المالونديالدهيد قدرة أجهزة مضادات الأكسدة، بما في ذلك الكلوتاثيون المُخفّض يؤدي هذا الخلل إلى تلف هيكلي ووظيفي في الأنسجة، وخاصةً في الأعضاء النشطة أيضيًا مثل الكبد. تُعدّ إنزيمات الكبد، مثل الانين امينوترانسفريس ,واسبارتيت امينو ترانسفريس ,الفوسفاتيز القاعدي والكاما كلوتامين ترانسفريس بمثابة مؤشرات كيميائية حيوية حساسة لتلف الخلايا الكبدية، والركود الصفراوي، واختلال وظائف القناة الصفراوية. وتهدف الدراسة إلى تقييم تاثير التعرض للكروم والرصاص في المنطقة الصناعية لمحافظة نينوى على وظائف الكبد والإجهاد التاكسدي وتركيز المعادن الثقيلة في مصل الدم والموشرات الحيوية للإجهاد التاكسدي وانزيمات وظائف الكبد مع مراعاة العمر والجنس .
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