THE USE OF BIO-NANOMATERIALS IN DRUG DELIVERY SYSTEMS: A PHYSICAL AND APPLIED STUDY

Abstract

Nanotechnology has come a long way in a short amount of time, making it possible to create highly effective, targeted, and controlled drug delivery systems based on bio-nanomaterials. These materials have amazing physical and chemical properties that make it possible for molecules and cells to interact with biological environments in very precise ways. This study looks at the role of bio-nanomaterials in drug delivery systems in great detail from a physical and practical point of view by combining pharmacokinetics, surface chemistry, transport physics, and biomedical performance evaluation. We look at four main types of bio-nanomaterials: polymeric nanoparticles, lipid-based nanocarriers, mesoporous silica nanoparticles, and protein-based nano carriers kinetics. We do this by using advanced diffusion modeling, simulated in-vitro release experiments, and cellular uptake. A large simulated dataset that includes experimental benchmarks from 2010 to 2024 is made and then looked at statistically. The results show that bio-nanomaterial-based delivery systems are better than traditional delivery methods at controlled drug release (over 95%), cellular uptake (up to 92%), and reducing toxicity (over 60%). This work makes it easier to move nanomedicine from research labs to clinical pharmaceutical engineering by providing a single physical-applied framework for optimizing nanocarriers.