Determination of several physiological, chemical, and histological aspects of the effect of Candida glabrata on the female reproductive system of white mice and their treatment with rosemary aqueous extract and amphotericin-B.

Abstract

     The present study aimed to determine the physiological, biochemical, and histological effects of Candida glabrata on the female reproductive system of mice and the therapeutic role of rosemary aqueous extract in the blood and reproductive system throughout the experiment period and to compare these effects with the role of this extract in synergy with amphotericin-B. The experiment lasted for (28) days. (35) mice were divided into 7 groups, each containing 5 mice, aged (16) weeks, which were first treated with estradiol hormone, except for the control group, to induce false menstruation, as it was injected with 0.5 mg subcutaneously for 6 days at a rate of one injection every two days before the start of the experiment. After that, a portion of these animals was vaginally injected with Candida glabrata fungus every two days for 6 days. After that, the experiment was conducted.