A study of the relationship between hsa-miR-5571-5p, rheumatoid factor, and the risk of developing rheumatoid arthritis in some Iraqi patients
DOI:
https://doi.org/10.31185/bsj.Vol23.Iss46.1892Keywords:
Rheumatoid Arthritis, rheumatoid factor (RF), hsa-miR‐5571-5pAbstract
Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes inflammation and progressive joint damage. Genetic and molecular factors play a significant role in disease development. This study focused on measuring of hsa-miR‐5571-5p and some immunological markers with the risk of Rheumatoid Arthritis. A total of 100 subjects were involved in a case-control study during their attendance at Al-Marjan Hospital / Babylon from March 2025 to February 2026. Subjects were divided into two groups, including 50 patients with rheumatoid arthritis (RA) under treatment and 50 control group. Blood samples were collected, and clinical and laboratory tests were performed, including measuring rheumatoid factor (RF). Results: The rheumatoid factor was positive in 94% of patients. The expression level of miRNA0557105p was significantly lower in the patient group than in the control group, 0.98 (0.56) versus 1.66 (0.84), respectively (p <0.001). Conclusion: The study concludes that a decrease in hsa-miR‐5571-5p, may contribute to the inflammatory and immune dysfunction mechanisms associated with rheumatoid arthritis. This suggests these molecules could serve as promising biomarkers for diagnosis and future monitoring of the disease.
References
References:
Abd El-Ghany, N. S., Siam, I. M., & Monir, A. M. (2019). Gender impact on rheumatoid arthritis disease characteristics in a cohort of Egyptian patients. Medical Journal of Cairo University, 87(3), 1895–1899.
Ahmad, R., & Zgair, A. (2021). Immunological and biological manifestation of rheumatoid arthritis patient in Iraq. Indian Journal of Forensic Medicine&Toxicology, 15(4), 1344–1350. https://doi.org/10.37506/ijfmt.v15i4.16896
Albarzinji, D., & Albustany, D. (2022). Association of 25-hydroxy vitamin D with IL-17 inflammatory cytokines, and osteoporosis in patients with rheumatoid arthritis in Kurdish nation/Iraq. The Open Rheumatology Journal, 16, e187431292210060. https://doi.org/10.2174/18743129-v16-e2210060
Al-Dabbagh, N. Y., & Hashim, Z. A. (2018). Evaluation of anti-CCP antibodies and rheumatoid factor for the laboratory diagnosis of rheumatoid arthritis. Duhok Medical Journal, 12(1), 41–54. https://doi.org/10.31386/dmj.uod.18.12.1.5
Alghamdi, M., Alamry, S. A., Bahlas, S. M., Uversky, V. N., & Redwan, E. M. (2022). Circulating extracellular vesicles and rheumatoid arthritis: A proteomic analysis. Cellular and Molecular Life Sciences, 79(1), 25. https://doi.org/10.1007/s00018-021-04020-4
Al-Saffar, E. A., Al-Saadi, B. Q. H., & Awadh, N. I. (2023). Study the association of miRNA-146a gene polymorphism and some immunological markers with the risk of rheumatoid arthritis incidence in a sample of Iraqi patients. Bionatura, 8(2), 1–14. https://doi.org/10.21931/RB/CSS/2023.08.02.22
Chauhan, K., Jandu, J. S., Brent, L. H., & Al-Dhahir, M. A. (2023). Rheumatoid arthritis. In StatPearls. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK441999/
Deane, K. D., & Holers, V. M. (2019). The natural history of rheumatoid arthritis. Clinical Therapeutics, 41(7), 1256–1269. https://doi.org/10.1016/j.clinthera.2019.04.028
Edilova, M. I., Akram, A., & Abdul-Sater, A. A. (2021). Innate immunity drives pathogenesis of rheumatoid arthritis. Biomedical Journal, 44(2), 172–182. https://doi.org/10.1016/j.bj.2020.06.010
Fujimori, K., Yoneda, T., Tomofuji, T., Ekuni, D., Azuma, T., Maruyama, T., Mizuno, H., & Morita, M. (2021). Detection of salivary miRNAs that predict chronic periodontitis progression: A cohort study. International Journal of Environmental Research and Public Health, 18(15), 8014. https://doi.org/10.3390/ijerph18158010
Garcia-Martin, R., Wang, G., Brandão, B. B., Zanotto, T. M., Shah, S., Kumar Patel, S., Schilling, B., & Kahn, C. R. (2022). MicroRNA sequence codes for small extracellular vesicle release and cellular retention. Nature, 601(7893), 446–451. https://doi.org/10.1038/s41586-021-04234-3
Jafat, S. M. (2021). Evaluation of the prognostic value of serum levels of soluble programmed death protein 1 (sPD-1) and soluble prog
Downloads
Published
Issue
Section
License
Copyright (c) 2026 ا.د إبراهيم التميمي جامعة القادسية / كلية الطب/ قسم الاحياء المجهرية الطبية، أنسام ناهض عباس جامعة القادسية / كلية الطب/ قسم الاحياء المجهرية الطبية
This work is licensed under a Creative Commons Attribution 4.0 International License.
